Causal neurodevelopmental origins of scoliosis: Multi-omics Mendelian randomization reveals brain–region–specific pathways and protein mediators

Background: The causal relationship between early-life central nervous system (CNS) infections and adolescent idiopathic scoliosis (AIS) remains unresolved, with limited evidence on mediating mechanisms linking neuroanatomical changes to spinal deformity. Method: Through three longitudinal cohorts (...

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Hauptverfasser:	Shuhao Zhang, Sisi Lu, Shiyu Chen, Xiangxiang Pan, Dongdong Xia, Lue Liu, Chenglong Xie, Majid Nisar, Aimin Wu, Xiaolei Zhang, Xiangyang Wang, Chongan Huang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-01-01
Schriftenreihe:	Journal of Orthopaedic Translation
Schlagworte:	Imaging-derived phenotypes Mendelian randomisation Retrospective cohort study Scoliosis UK Biobank Viral encephalitis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2214031X25001615
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