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Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center

Abstract Background Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the M15A family that, besides having the characteristic zinc coordination...

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Autors principals: Carina Jägers, Henk Roelink
Format: Artigo
Idioma:Inglês
Publicat: BMC 2021-04-01
Col·lecció:BMC Molecular and Cell Biology
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Accés en línia:https://doi.org/10.1186/s12860-021-00359-5
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