NeuroD1-USP1-MYCN axis drives tumor progression in neuroblastoma

Abstract Background Neuroblastoma, originating from the sympathetic neural crest, is the most prevalent extracranial solid tumor in children. Amplification of MYCN is a widely recognized indicator of poor prognosis in neuroblastoma. However, the structural properties of the N-Myc protein encoded by...

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Autors principals:	Gen Li, Yanling Chen, Ran Zhuo, Juanjuan Yu, Jianping Bao, Di Wu, Hongli Yin, Xiaolu Li, Zhiheng Li, Chun Yang, Hairong Wang, Fang Fang, Yunyun Xu, Xiaohan Hu, Chenxi Feng, Mei Li, Lixiao Xu, Duancheng Guo, Li Zhang, Chaonan Zheng, Xiaodong Wang, Yuan Wang, Zimu Zhang, Jian Pan
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Neuroblastoma NeuroD1 USP1 MYCN Pimozide
Accés en línia:	https://doi.org/10.1186/s12967-026-07844-5
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