C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition

Objective: Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells. We initially observed that high expression of C/EBPβ-LIP makes c...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Tobias Ackermann, Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, Martijn G.S. Rutten, Mathilde J.C. Broekhuis, Mohamad Amr Zaini, Götz Hartleben, Cornelis F. Calkhoven
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-06-01
coleção:	Molecular Metabolism
Assuntos:	C/EBPβ Malate-aspartate shuttle Glycolysis NAD+ Cancer
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877823000601
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!