A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS

Tumor necrosis factor (TNF) causes a lethal systemic inflammatory response syndrome (SIRS) which is characterized by significant metabolic alterations. Based on liver RNA sequencing, we found that TNF impairs the malate-aspartate shuttle (MAS), an essential redox shuttle that transfers reducing equi...

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Autors principals:	Louise Nuyttens, Marah Heyerick, Maxime Roes, Elise Moens, Céline Van Dender, Charlotte Wallaeys, Tino Hochepied, Steven Timmermans, Jolien Vandewalle, Claude Libert
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-10-01
Col·lecció:	Frontiers in Immunology
Matèries:	malate aspartate shuttle citrin TNF-induced SIRS lipid metabolism carbohydrate metabolism
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1652516/full
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