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C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition

Objective: Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells. We initially observed that high expression of C/EBPβ-LIP makes c...

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Principais autores: Tobias Ackermann, Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, Martijn G.S. Rutten, Mathilde J.C. Broekhuis, Mohamad Amr Zaini, Götz Hartleben, Cornelis F. Calkhoven
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-06-01
Serier:Molecular Metabolism
Fag:
C/EBPβ
Malate-aspartate shuttle
Glycolysis
NAD+
Cancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877823000601
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