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Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a possible mechanism of activation by acyl-modified gh...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Yuki Shiimura, Shoichiro Horita, Akie Hamamoto, Hidetsugu Asada, Kunio Hirata, Misuzu Tanaka, Kenji Mori, Tomoko Uemura, Takuya Kobayashi, So Iwata, Masayasu Kojima
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2020-08-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-020-17554-1
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