Functionally selective activation of the dopamine receptor D2 is mirrored by the protein expression profiles

Abstract The development of functionally selective or biased ligands is a promising approach towards drugs with less side effects. Biased ligands for G protein-coupled receptors can selectively induce G protein activation or β-arrestin recruitment. The consequences of this selective action on cellul...

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Hlavní autoři:	Deborah Wenk, Vladimir Ignatchenko, Andrew Macklin, Harald Hübner, Peter Gmeiner, Dorothée Weikert, Monika Pischetsrieder, Thomas Kislinger
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2021-02-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-021-83038-x
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