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A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by β-Amyloid in Glial Cells

Neurodegenerative diseases (NDDs) are progressive multifactorial disorders of the nervous system sharing common pathogenic features, including intracellular misfolded protein aggregation, mitochondrial deficit, and inflammation. Taking into consideration the multifaceted nature of NDDs, development...

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Principais autores: Beatrice Polini, Lorenzo Zallocco, Francesca Gado, Rebecca Ferrisi, Caterina Ricardi, Mariachiara Zuccarini, Vittoria Carnicelli, Clementina Manera, Maurizio Ronci, Antonio Lucacchini, Riccardo Zucchi, Laura Giusti, Grazia Chiellini
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-05-01
coleção:Cells
Assuntos:
cannabinoid receptor type II (CBR2)
autophagy
neuroinflammation
proteomic
β-amyloid
TFEB
Acesso em linha:https://www.mdpi.com/2073-4409/13/10/875
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