Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states

Summary: Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer with identical affinity (Kd ∼2 nM). Contrary to t...

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Ngā kaituhi matua:	Ravi Jasuja, Daniel Spencer, Abhilash Jayaraj, Liming Peng, Meenakshi Krishna, Brian Lawney, Priyank Patel, Bhyravabhotla Jayaram, Kelly M. Thayer, David L. Beveridge, Shalender Bhasin
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2021-06-01
Rangatū:	iScience
Ngā marau:	Biochemistry Endocrinology
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2589004221003825
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!