Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states

Summary: Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer with identical affinity (Kd ∼2 nM). Contrary to t...

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Detalhes bibliográficos

Principais autores:	Ravi Jasuja, Daniel Spencer, Abhilash Jayaraj, Liming Peng, Meenakshi Krishna, Brian Lawney, Priyank Patel, Bhyravabhotla Jayaram, Kelly M. Thayer, David L. Beveridge, Shalender Bhasin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-06-01
coleção:	iScience
Assuntos:	Biochemistry Endocrinology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004221003825
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