Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states

Summary: Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer with identical affinity (Kd ∼2 nM). Contrary to t...

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Autors principals:	Ravi Jasuja, Daniel Spencer, Abhilash Jayaraj, Liming Peng, Meenakshi Krishna, Brian Lawney, Priyank Patel, Bhyravabhotla Jayaram, Kelly M. Thayer, David L. Beveridge, Shalender Bhasin
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-06-01
Col·lecció:	iScience
Matèries:	Biochemistry Endocrinology
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2589004221003825
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