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Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis

BackgroundSystemic sclerosis (SSc) is an autoimmune disease characterized by overproduction of extracellular matrix (ECM) and multiorgan fibrosis. Animal studies pointed to bone marrow-derived cells as a potential source of pathological ECM-producing cells in immunofibrotic disorders. So far, involv...

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Principais autores: Michał Rudnik, Amela Hukara, Ievgeniia Kocherova, Suzana Jordan, Janine Schniering, Vincent Milleret, Martin Ehrbar, Karin Klingel, Carol Feghali-Bostwick, Oliver Distler, Przemysław Błyszczuk, Gabriela Kania
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-08-01
coleção:Frontiers in Immunology
Assuntos:
systemic sclerosis
CD14+ monocytes
CD14+ macrophages
fibrosis
fibronectin
TGF-β
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642891/full
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