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Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis

BackgroundSystemic sclerosis (SSc) is an autoimmune disease characterized by overproduction of extracellular matrix (ECM) and multiorgan fibrosis. Animal studies pointed to bone marrow-derived cells as a potential source of pathological ECM-producing cells in immunofibrotic disorders. So far, involv...

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Main Authors: Michał Rudnik, Amela Hukara, Ievgeniia Kocherova, Suzana Jordan, Janine Schniering, Vincent Milleret, Martin Ehrbar, Karin Klingel, Carol Feghali-Bostwick, Oliver Distler, Przemysław Błyszczuk, Gabriela Kania
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
CD14+ monocytes
CD14+ macrophages
fibrosis
fibronectin
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642891/full
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