Ergosterol-depleted clinical isolates of Nakaseomyces glabratus can develop multi-drug resistance without severe fitness defects or attenuated virulence in an invertebrate infection model

ABSTRACT Nakaseomyces glabratus (formerly Candida glabrata) is a leading cause of invasive candidiasis and rapidly develops antifungal drug resistance during treatment. An increasing number of clinical isolates show reduced susceptibility to echinocandins and azoles, leaving amphotericin B (AMB) as...

Description complète

Détails bibliographiques

Auteurs principaux:	Alexander M. Aldejohann, Nadja Thielemann, Aina Martinez Zurita, Christoph Müller, Tom Gräfenhan, Richard Kriz, Heimo Lagler, Isabell S. Behr, Nathalie Reus, Annika Schöninger, Grit Walther, Lena-Marie Mazan, Hannah Wilhelm, Birgit Willinger, Christina A. Cuomo, Oliver Kurzai, Ronny Martin
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2026-06-01
Collection:	mBio
Sujets:	Nakaseomyces glabratus amphotericin B ergosterol depletion multidrug resistance
Accès en ligne:	https://journals.asm.org/doi/10.1128/mbio.02731-25
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!