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Ergosterol-depleted clinical isolates of Nakaseomyces glabratus can develop multi-drug resistance without severe fitness defects or attenuated virulence in an invertebrate infection model

ABSTRACT Nakaseomyces glabratus (formerly Candida glabrata) is a leading cause of invasive candidiasis and rapidly develops antifungal drug resistance during treatment. An increasing number of clinical isolates show reduced susceptibility to echinocandins and azoles, leaving amphotericin B (AMB) as...

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Principais autores: Alexander M. Aldejohann, Nadja Thielemann, Aina Martinez Zurita, Christoph Müller, Tom Gräfenhan, Richard Kriz, Heimo Lagler, Isabell S. Behr, Nathalie Reus, Annika Schöninger, Grit Walther, Lena-Marie Mazan, Hannah Wilhelm, Birgit Willinger, Christina A. Cuomo, Oliver Kurzai, Ronny Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2026-06-01
coleção:mBio
Assuntos:
Nakaseomyces glabratus
amphotericin B
ergosterol depletion
multidrug resistance
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.02731-25
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