Ergosterol-depleted clinical isolates of Nakaseomyces glabratus can develop multi-drug resistance without severe fitness defects or attenuated virulence in an invertebrate infection model

ABSTRACT Nakaseomyces glabratus (formerly Candida glabrata) is a leading cause of invasive candidiasis and rapidly develops antifungal drug resistance during treatment. An increasing number of clinical isolates show reduced susceptibility to echinocandins and azoles, leaving amphotericin B (AMB) as...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Alexander M. Aldejohann, Nadja Thielemann, Aina Martinez Zurita, Christoph Müller, Tom Gräfenhan, Richard Kriz, Heimo Lagler, Isabell S. Behr, Nathalie Reus, Annika Schöninger, Grit Walther, Lena-Marie Mazan, Hannah Wilhelm, Birgit Willinger, Christina A. Cuomo, Oliver Kurzai, Ronny Martin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2026-06-01
Edice:	mBio
Témata:	Nakaseomyces glabratus amphotericin B ergosterol depletion multidrug resistance
On-line přístup:	https://journals.asm.org/doi/10.1128/mbio.02731-25
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!