Hyperglycemia drives lmmune evasion in colorectal cancer through VISTA stabilization

Abstract Hyperglycemia, the defining feature of diabetes mellitus, enhances cancer immune evasion through multiple mechanisms. V-domain immunoglobulin suppressor of T cell activation (VISTA) overexpression in tumor cells induces CD8⁺ T cell exhaustion, thereby promoting immune evasion. However, whet...

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Detalhes bibliográficos

Principais autores:	Xin Liu, Qian Liu, Dong Guo, Zezhou Zhao, Jing Wang, Yaoxian Xiang, Kangjie Wang, Lijun Yang, Ke Zhu, Li Wang, Ruofan Li, Xu Gao, Chan Zhang, Yurong Cheng, Dong Yan, Yingying Tong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
Colecção:	Cell Communication and Signaling
Assuntos:	Colorectal cancer VISTA USP22 Hyperglycemia Immune evasion Phosphorylation
Acesso em linha:	https://doi.org/10.1186/s12964-025-02642-w
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