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Targeting USP8 Inhibits O‐GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT

Abstract Hepatocellular carcinoma (HCC) is a lethal and aggressive human malignancy. The present study examins the anti‐tumor effects of deubiquitylating enzymes (DUB) inhibitors in HCC. It is found that the inhibitor of ubiquitin specific peptidase 8 (USP8) and DUB‐IN‐3 shows the most effective ant...

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Main Authors: Jianing Tang, Guo Long, Kuan Hu, Desheng Xiao, Shuang Liu, Liang Xiao, Ledu Zhou, Yongguang Tao
Format: Artigo
Language:Inglês
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
deubiquitylation
ferroptosis
O‐GlcNAcylation
OGT
USP8
Online Access:https://doi.org/10.1002/advs.202302953
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