S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

Extracellular aggregation of the amyloid-β 1–42 (Aβ42) peptide is a major hallmark of Alzheimer’s disease (AD), with recent data suggesting that Aβ intermediate oligomers (AβO) are more cytotoxic than mature amyloid fibrils. Understanding how chaperones harness such amyloid oligomers is critical tow...

Celý popis

Podrobná bibliografie

Hlavní autoři:	António J. Figueira, Joana Saavedra, Isabel Cardoso, Cláudio M. Gomes
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-03-01
Edice:	Frontiers in Neuroscience
Témata:	molecular chaperones protein aggregation amyloid-β oligomers aggregation kinetics and mechanism amyloid beta (1–42)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1162741/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!