S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

Extracellular aggregation of the amyloid-β 1–42 (Aβ42) peptide is a major hallmark of Alzheimer’s disease (AD), with recent data suggesting that Aβ intermediate oligomers (AβO) are more cytotoxic than mature amyloid fibrils. Understanding how chaperones harness such amyloid oligomers is critical tow...

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Principais autores:	António J. Figueira, Joana Saavedra, Isabel Cardoso, Cláudio M. Gomes
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2023-03-01
Serija:	Frontiers in Neuroscience
Teme:	molecular chaperones protein aggregation amyloid-β oligomers aggregation kinetics and mechanism amyloid beta (1–42)
Online dostop:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1162741/full
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