Regulatory role of serine 59 in the oligomeric dynamics and chaperone function of αB-crystallin

Abstract We previously demonstrated that deletion of the 54FLRAPSW61 sequence, containing the key phosphorylation site serine 59 (S59), resulted in a two-fold reduction in oligomeric mass and a ten-fold enhancement of αB-crystallin’s chaperone activity. This study examined whether targeted deletion...

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Hlavní autoři:	Tenzin Tender, Puttur Santhoshkumar, Leena Suleiman, Md Rejaul Hoq, K. Krishna Sharma
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-10-01
Edice:	Scientific Reports
Témata:	αB-crystallin Oligomer Chaperone Phosphomimic Interactions Zeta potential
On-line přístup:	https://doi.org/10.1038/s41598-025-21161-9
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