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Regulatory role of serine 59 in the oligomeric dynamics and chaperone function of αB-crystallin

Abstract We previously demonstrated that deletion of the 54FLRAPSW61 sequence, containing the key phosphorylation site serine 59 (S59), resulted in a two-fold reduction in oligomeric mass and a ten-fold enhancement of αB-crystallin’s chaperone activity. This study examined whether targeted deletion...

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Main Authors: Tenzin Tender, Puttur Santhoshkumar, Leena Suleiman, Md Rejaul Hoq, K. Krishna Sharma
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2025-10-01
Series:Scientific Reports
Subjects:
αB-crystallin
Oligomer
Chaperone
Phosphomimic
Interactions
Zeta potential
Online Access:https://doi.org/10.1038/s41598-025-21161-9
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