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Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Abstract Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with disease pathology. Oxidative stress induced bunina and lewy bodies formation...

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Principais autores: Surinder Pal, Abha Tiwari, Kaushal Sharma, Suresh Kumar Sharma
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-10-01
Serier:BMC Neuroscience
Fag:
Amyotrophic lateral sclerosis
SOD1
PolyPhen2
QMEAN
Ramachandran plot
PHP-SNP
Online adgang:http://link.springer.com/article/10.1186/s12868-020-00591-3
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