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The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1

The biogenesis of 60S ribosomal subunits is initiated in the nucleus where rRNAs and proteins form pre-60S particles. These pre-60S particles mature by transiently interacting with various assembly factors. The ~5000 amino-acid AAA+ ATPase Rea1 (or Midasin) generates force to mechanically remove ass...

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Sparad:
Huvudupphov: Piotr Sosnowski, Linas Urnavicius, Andreas Boland, Robert Fagiewicz, Johan Busselez, Gabor Papai, Helgo Schmidt
Materialtyp: Artigo
Språk:Inglês
Utgiven: eLife Sciences Publications Ltd 2018-11-01
Serie:eLife
Ämnen:
Rea1
midasin
CryoEM
ribosome maturation
AAA+ protein
molecular machine
Länkar:https://elifesciences.org/articles/39163
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