AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

Pancreatic KATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the KATP channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used KATP channel inhibitors have been shown to act as pharmacochaperones and restore surface expres...

詳細記述

書誌詳細

主要な著者:	Assmaa Elsheikh, Camden M Driggers, Ha H Truong, Zhongying Yang, John Allen, Niel M Henriksen, Katarzyna Walczewska-Szewc, Show-Ling Shyng
フォーマット:	Artigo
言語:	Inglês
出版事項:	eLife Sciences Publications Ltd 2025-03-01
シリーズ:	eLife
主題:	ATP-sensitive potassium channel cryoEM structure pharmacological chaperones drug discovery Mesocricetus auratus
オンライン･アクセス:	https://elifesciences.org/articles/103159
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!