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AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

Pancreatic KATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the KATP channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used KATP channel inhibitors have been shown to act as pharmacochaperones and restore surface expres...

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Furkejuvvon:
Váldodahkkit: Assmaa Elsheikh, Camden M Driggers, Ha H Truong, Zhongying Yang, John Allen, Niel M Henriksen, Katarzyna Walczewska-Szewc, Show-Ling Shyng
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: eLife Sciences Publications Ltd 2025-03-01
Ráidu:eLife
Fáttát:
ATP-sensitive potassium channel
cryoEM structure
pharmacological chaperones
drug discovery
Mesocricetus auratus
Liŋkkat:https://elifesciences.org/articles/103159
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