AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

Pancreatic KATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the KATP channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used KATP channel inhibitors have been shown to act as pharmacochaperones and restore surface expres...

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Autors principals:	Assmaa Elsheikh, Camden M Driggers, Ha H Truong, Zhongying Yang, John Allen, Niel M Henriksen, Katarzyna Walczewska-Szewc, Show-Ling Shyng
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2025-03-01
Col·lecció:	eLife
Matèries:	ATP-sensitive potassium channel cryoEM structure pharmacological chaperones drug discovery Mesocricetus auratus
Accés en línia:	https://elifesciences.org/articles/103159
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