Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat

The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hypertension in rats. Female rats were dosed with sugen (3...

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Bibliografische gegevens

Hoofdauteurs:	Craig K. Docherty, Nina Denver, Simon Fisher, Margaret Nilsen, Dianne Hillyard, Rebecca L. Openshaw, Hicham Labazi, Margaret R. MacLean
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Elsevier 2020-12-01
Reeks:	Molecular Therapy: Nucleic Acids
Onderwerpen:	pulmonary hypertension serotonin microRNA96
Online toegang:	http://www.sciencedirect.com/science/article/pii/S2162253120302730
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