ROC‐325 Attenuates Hypoxia‐Induced Pulmonary Hypertension Through Dual Inhibition of Autophagy and Hypoxia‐Inducible Factor 2α Signaling

ABSTRACT The activation of autophagy in endothelial cells is a key mechanism underlying vascular remodeling, leading to the development and progression of pulmonary hypertension (PH). In our previous studies, we developed ROC‐325, a novel lysosomal autophagy inhibitor, and demonstrated its potent th...

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Hauptverfasser:	Changlei Bao, Shuxin Liang, Dingyuan Liu, Xingting Wang, Dan Bai, Chuangjia Huang, Hanliang Sun, Zi Yang, Bitao Wu, Zixuan Chen, Jieyi Feng, Zinan Luo, Jintao Long, Jinsheng Zhu, June Bai, Li Zhang, Aiai Chu, Caojin Zhang, Haiyang Tang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-03-01
Schriftenreihe:	MedComm – Future Medicine
Schlagworte:	autophagy autophagy inhibitor ROC‐325 endothelial cells HIF‐2α hypoxia pulmonary hypertension
Online-Zugang:	https://doi.org/10.1002/mef2.70045
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