Hypoxia Inducible Factor Signaling and Experimental Persistent Pulmonary Hypertension of the Newborn: A Therapeutic Opportunity

BACKGROUND: Mitochondrial reactive oxygen species levels and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) activity are increased in a lamb model of persistent pulmonary hypertension of the newborn (PPHN). These events can trigger hypoxia inducible factor (HIF) signaling in r...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Stephen eWedgwood, Satyan eLakshminrusimha, Paul T Schumacker, Robin eSteinhorn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2015-03-01
Edice:	Frontiers in Pharmacology
Témata:	Reactive Oxygen Species hypoxia pulmonary hypertension Vascular Stress HIF-1α.
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00047/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!