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Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway

Abstract Ferroptosis is a recently identified form of programmed cell death that plays an important role in the pathophysiological process of osteoarthritis (OA). Herein, we investigated the protective effect of moderate mechanical stress on chondrocyte ferroptosis and further revealed the internal...

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Principais autores: Juanjuan Han, Li-nan Zhan, Yue Huang, Shijia Guo, Xiaoding Zhou, Leonid Kapilevich, Zhuo Wang, Ke Ning, Mingli Sun, Xin-an Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-03-01
Serier:Scientific Reports
Fag:
Mechanical stress
Osteoarthritis
Ferroptosis
Cartilage
Online adgang:https://doi.org/10.1038/s41598-024-55629-x
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