Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway

Abstract Ferroptosis is a recently identified form of programmed cell death that plays an important role in the pathophysiological process of osteoarthritis (OA). Herein, we investigated the protective effect of moderate mechanical stress on chondrocyte ferroptosis and further revealed the internal...

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Autori principali:	Juanjuan Han, Li-nan Zhan, Yue Huang, Shijia Guo, Xiaoding Zhou, Leonid Kapilevich, Zhuo Wang, Ke Ning, Mingli Sun, Xin-an Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-03-01
Serie:	Scientific Reports
Soggetti:	Mechanical stress Osteoarthritis Ferroptosis Cartilage
Accesso online:	https://doi.org/10.1038/s41598-024-55629-x
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