Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway

Abstract Ferroptosis is a recently identified form of programmed cell death that plays an important role in the pathophysiological process of osteoarthritis (OA). Herein, we investigated the protective effect of moderate mechanical stress on chondrocyte ferroptosis and further revealed the internal...

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Ngā kaituhi matua:	Juanjuan Han, Li-nan Zhan, Yue Huang, Shijia Guo, Xiaoding Zhou, Leonid Kapilevich, Zhuo Wang, Ke Ning, Mingli Sun, Xin-an Zhang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2024-03-01
Rangatū:	Scientific Reports
Ngā marau:	Mechanical stress Osteoarthritis Ferroptosis Cartilage
Urunga tuihono:	https://doi.org/10.1038/s41598-024-55629-x
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!