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IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors

Abstract Cells that are exposed to harmful genetic damage, either from internal or external sources, may undergo senescence if they are unable to repair their DNA. Senescence, characterized by a state of irreversible growth arrest, can spread to neighboring cells through a process known as the senes...

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Detalhes bibliográficos
Principais autores: Nicola Alessio, Domenico Aprile, Gianfranco Peluso, Valeria Mazzone, Deanira Patrone, Giovanni Di Bernardo, Umberto Galderisi
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-02-01
coleção:Cell Communication and Signaling
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Acesso em linha:https://doi.org/10.1186/s12964-024-01469-1
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