Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

Summary: To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate disease phenotypes in vitro. Mole...

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Hauptverfasser: Minori Ohashi, Elena Korsakova, Denise Allen, Peiyee Lee, Kai Fu, Benni S. Vargas, Jessica Cinkornpumin, Carlos Salas, Jenny C. Park, Igal Germanguz, Justin Langerman, Contantinos Chronis, Edward Kuoy, Stephen Tran, Xinshu Xiao, Matteo Pellegrini, Kathrin Plath, William E. Lowry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018-05-01
Schriftenreihe:Stem Cell Reports
Online Zugang:http://www.sciencedirect.com/science/article/pii/S221367111830153X
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