Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures

This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan (LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect of three independent factors (Span 60 amount, chitosan concentration, and cholesterol amount) on vesicle size, entrapment eff...

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Үндсэн зохиолчид:	Alaa S. Tulbah, Mohammed H. Elkomy, Randa Mohammed Zaki, Hussein M. Eid, Essam M. Eissa, Adel A. Ali, Heba A. Yassin, Basmah Nasser Aldosari, Ibrahim A. Naguib, Amira H. Hassan
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2023-12-01
Цуврал:	International Journal of Pharmaceutics: X
Нөхцлүүд:	Intranasal Pharmacokinetics Nose-to-brain delivery Focal seizures Antiepileptic Chitosomes
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2590156723000506
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!