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Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures

This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan (LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect of three independent factors (Span 60 amount, chitosan concentration, and cholesterol amount) on vesicle size, entrapment eff...

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Principais autores: Alaa S. Tulbah, Mohammed H. Elkomy, Randa Mohammed Zaki, Hussein M. Eid, Essam M. Eissa, Adel A. Ali, Heba A. Yassin, Basmah Nasser Aldosari, Ibrahim A. Naguib, Amira H. Hassan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-12-01
Serier:International Journal of Pharmaceutics: X
Fag:
Intranasal
Pharmacokinetics
Nose-to-brain delivery
Focal seizures
Antiepileptic
Chitosomes
Online adgang:http://www.sciencedirect.com/science/article/pii/S2590156723000506
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