Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures

This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan (LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect of three independent factors (Span 60 amount, chitosan concentration, and cholesterol amount) on vesicle size, entrapment eff...

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Principais autores:	Alaa S. Tulbah, Mohammed H. Elkomy, Randa Mohammed Zaki, Hussein M. Eid, Essam M. Eissa, Adel A. Ali, Heba A. Yassin, Basmah Nasser Aldosari, Ibrahim A. Naguib, Amira H. Hassan
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2023-12-01
叢編:	International Journal of Pharmaceutics: X
主題:	Intranasal Pharmacokinetics Nose-to-brain delivery Focal seizures Antiepileptic Chitosomes
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2590156723000506
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