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Exploiting a rodent cell block for intrinsic resistance to HIV-1 gene expression in human T cells

ABSTRACT HIV-1 virion production is inefficient in cells derived from mice and other rodents reflecting cell-intrinsic defects to interactions between the HIV-1 auxiliary proteins Tat and Rev and host dependency factors CCNT1 (Cyclin T1) and XPO1 (exportin-1, also known as CRM1), respectively. In hu...

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Furkejuvvon:
Váldodahkkit: Ryan T. Behrens, Jyothi Krishnaswamy Rajashekar, James W. Bruce, Edward L. Evans, Amelia M. Hansen, Natalia Salazar-Quiroz, Lacy M. Simons, Paul Ahlquist, Judd F. Hultquist, Priti Kumar, Nathan M. Sherer
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Microbiology 2023-10-01
Ráidu:mBio
Fáttát:
human immunodeficiency virus
lentiviruses
transcription
nuclear export
Cyclin T1
CCNT1
Liŋkkat:https://journals.asm.org/doi/10.1128/mbio.00420-23
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