Exploiting a rodent cell block for intrinsic resistance to HIV-1 gene expression in human T cells

ABSTRACT HIV-1 virion production is inefficient in cells derived from mice and other rodents reflecting cell-intrinsic defects to interactions between the HIV-1 auxiliary proteins Tat and Rev and host dependency factors CCNT1 (Cyclin T1) and XPO1 (exportin-1, also known as CRM1), respectively. In hu...

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Principais autores:	Ryan T. Behrens, Jyothi Krishnaswamy Rajashekar, James W. Bruce, Edward L. Evans, Amelia M. Hansen, Natalia Salazar-Quiroz, Lacy M. Simons, Paul Ahlquist, Judd F. Hultquist, Priti Kumar, Nathan M. Sherer
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2023-10-01
Serija:	mBio
Teme:	human immunodeficiency virus lentiviruses transcription nuclear export Cyclin T1 CCNT1
Online dostop:	https://journals.asm.org/doi/10.1128/mbio.00420-23
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