Dexamethasone inhibits M ycobacterium tuberculosis-induced glycolysis but preserves antimicrobial function in primary human macrophages

Abstract Glucocorticoids (GC) are useful adjunctive host directed therapies (HDT) for sub-types of tuberculosis (TB). Macrophages play a central role in controlling Mycobacterium tuberculosis (Mtb) infection, relying on glycolytic reprogramming to support an effective host defence, yet the influence...

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Detalhes bibliográficos

Principais autores:	Lorraine Thong, Olivia Sandby Thomas, Oisin Ó Gallchobhair, Emily Duffin, Anjali S. Yennemadi, Gina Leisching, Dearbhla M. Murphy, Parthiban Nadarajan, Finbarr O’Connell, Mary P. O’Sullivan, Sharee A. Basdeo, Donal J. Cox, Joseph Keane
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-10-01
coleção:	Scientific Reports
Assuntos:	Human alveolar macrophage Glycolysis Oxidative phosphorylation Immunometabolism Mycobacterium tuberculosis Steroid
Acesso em linha:	https://doi.org/10.1038/s41598-025-20188-2
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