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Dexamethasone inhibits M ycobacterium tuberculosis-induced glycolysis but preserves antimicrobial function in primary human macrophages

Abstract Glucocorticoids (GC) are useful adjunctive host directed therapies (HDT) for sub-types of tuberculosis (TB). Macrophages play a central role in controlling Mycobacterium tuberculosis (Mtb) infection, relying on glycolytic reprogramming to support an effective host defence, yet the influence...

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Principais autores: Lorraine Thong, Olivia Sandby Thomas, Oisin Ó Gallchobhair, Emily Duffin, Anjali S. Yennemadi, Gina Leisching, Dearbhla M. Murphy, Parthiban Nadarajan, Finbarr O’Connell, Mary P. O’Sullivan, Sharee A. Basdeo, Donal J. Cox, Joseph Keane
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-10-01
Serier:Scientific Reports
Fag:
Human alveolar macrophage
Glycolysis
Oxidative phosphorylation
Immunometabolism
Mycobacterium tuberculosis
Steroid
Online adgang:https://doi.org/10.1038/s41598-025-20188-2
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