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Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention

Cells have evolved a complex molecular network, collectively called the protein homeostasis (proteostasis) network, to produce and maintain proteins in the appropriate conformation, concentration and subcellular localization. Loss of proteostasis leads to a reduction in cell viability, which occurs...

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Principais autores: Laleh Khodaparast, Guiqin Wu, Ladan Khodaparast, Béla Z. Schmidt, Frederic Rousseau, Joost Schymkowitz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-06-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
protein homeostasis
protein aggregation
antibacterial peptide
Pept-in
inclusion body
aggregation-prone region
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2021.681855/full
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