Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies

A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This nonenzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration and other di...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Catherine eEakin, Amanda eMiller, Jennifer eKerr, James eKung, Alison eWallace
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2014-04-01
סדרה:	Frontiers in Pharmacology
נושאים:	Isoaspartic Acid Hydrophyobic Interaction Chromatography Peptide Map IdeS Fabricator
גישה מקוונת:	http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00087/full
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!