Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies
A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This nonenzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration and other di...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Frontiers Media S.A.
2014-04-01
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| Seri Bilgileri: | Frontiers in Pharmacology |
| Konular: | |
| Online Erişim: | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00087/full |
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