Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies
A ubiquitous post-translational modification observed in proteins is isomerization of aspartic acid to isoaspartic acid (isoAsp). This nonenzymatic post-translational modification occurs spontaneously in proteins and plays a role in aging, autoimmune response, cancer, neurodegeneration and other di...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2014-04-01
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| Serie: | Frontiers in Pharmacology |
| Soggetti: | |
| Accesso online: | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00087/full |
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