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Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction

Summary: CD133 is widely used as a marker to isolate tumor-initiating cells in many types of cancers. The structure of N-glycan on CD133 is altered during the differentiation of tumor-initiating cells. However, the relationship between CD133 N-glycosylation and stem cell characteristics remains elus...

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Principais autores: Yuanyan Wei, Qihang Chen, Jiayue Chen, Chenhao Zhou, Shuting Geng, Danfang Shi, Sijing Huang, Zhiwei Liang, Xiaoning Chen, Ning Ren, Jianhai Jiang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-12-01
Serier:Cell Reports
Fag:
CP: Cancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124723016005
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