Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction

Summary: CD133 is widely used as a marker to isolate tumor-initiating cells in many types of cancers. The structure of N-glycan on CD133 is altered during the differentiation of tumor-initiating cells. However, the relationship between CD133 N-glycosylation and stem cell characteristics remains elus...

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Principais autores:	Yuanyan Wei, Qihang Chen, Jiayue Chen, Chenhao Zhou, Shuting Geng, Danfang Shi, Sijing Huang, Zhiwei Liang, Xiaoning Chen, Ning Ren, Jianhai Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-12-01
coleção:	Cell Reports
Assuntos:	CP: Cancer
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124723016005
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