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SLC30 (ZnT) and SLC39 (ZIP) zinc transporter families: from gatekeepers of zinc homeostasis to promoters of tumorigenesis and targets for clinical therapy

Zinc is a trace element that plays important functions in gene expression, enzymatic activity and cellular signaling. Cellular zinc homeostasis is tightly regulated by two solute carrier families: SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, zrt- and irt-like protein), which are responsible for the...

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Main Authors: Yuqiao Zhou, Guangfa Huang, Mengling Liu, Minghui Zhang, Bowen Wu, Jinke Gu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-01-01
Series:Frontiers in Immunology
Subjects:
clinical translation
SLC30 (ZnT)
SLC39 (ZIP)
therapeutic targets
tumorigenesis
zinc homeostasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1750534/full
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